产品货号：
Z22960
中文名称：
PARK2/Parkin/PRKN抗体
英文名称：
Anti-PARK2/Parkin/PRKN Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PARK2/Parkin/PRKN Antibody |
| 指标别名 | AR JP;LPRS2;PARK2;PARK2/Parkin;Parkin;Parkinson disease protein 2;PDJ;PRKN |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC |
| 基因名称 | PRKN |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human Parkin recombinant protein (Position:I23-K416).Human Parkin shares 82% and 84% amino acid (aa) sequence identity with mouse and rat Parkin,respectively. |
| 实际分子量 | 66KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Parkin is a RING domain-containing E3 ubiquitin ligase involved in proteasome-dependent degradation of proteins.It is mapped to 6q26.This gene is important for mitochondrial quality control by lysosome-dependent degradation of damaged mitochondria through autophagy,or mitophagy.Parkin is expressed in neuronal processes and cell bodies of neurons,but not glial cells,in the midbrain,basal ganglia,cerebral cortex,and cerebellum.Parkin assimilated with actin filaments,suggesting that it is a cytoskeletal-associated protein.Parkin is identified as a transcriptional repressor of p53 independent of its ubiquitin ligase function.It also has been found that parkin was associated physically with mitochondrial DNA (mtDNA) in proliferating as well as in differentiated SH-SY5Y neuroblastoma cells. |
| Uniprot ID | O60260 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | parkin RBR E3 ubiquitin protein ligase |
| 蛋白名全称 | E3 ubiquitin-protein ligase parkin |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunocytochemistry 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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